Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.


Bipolar Disorder

(Manic-Depressive Illness; Manic Depression; Manic Disorder; Manic Affective Disorder)
Definition

Bipolar disorder results in extreme swings in mood, energy, and ability to function. The mood changes of bipolar disorder are more dramatic than normal ups and downs. They can hurt relationships and cause poor job or school performance. Bipolar disorder can be treated. Contact your doctor if you think you may have this condition.

The two mood extremes of bipolar disorder are mania and depression. In mania, one of the defining symptoms is an increase in energy and a decreased need for sleep. The mood may be overly happy or irritable. In depression , a down mood with fatigue takes over, and it is often accompanied with irritability.

There are two forms of this condition:

  • Bipolar I disorder—involves recurrent episodes of mania often immediately followed by depression
  • Bipolar II disorder—involves milder episodes of mania (called hypomania) that alternate with episodes of depression
Causes

The cause of bipolar disorder is not known. This condition tends to run in families. Specific genes may play a role. It is most likely many different genes that act together.

Risk Factors

A family history of the disorder increases your chance of developing it. Tell your doctor if you have a family member with bipolar disorder.

Symptoms

Symptoms include:

  • Dramatic mood swings—This can range from elated excitability, unrealistic goal setting, and an exaggerated sense of self to hopeless despondency.
  • Extreme changes in energy and behavior
  • Periods of normal mood in between ups and downs

Signs and symptoms of mania include:

  • Decreased need for sleep
  • Increased energy and effort toward goal-directed activities
  • Overconfidence or inflated self-esteem
  • Persistent and inexplicable elevation in mood
  • Poor judgment, often involving spending sprees and sexual indiscretions
  • Racing thoughts, jumping from one idea to another
  • Rapid speech or pressure to keep talking
  • Restlessness and agitation
  • Trouble concentrating

Signs and symptoms of depression include:

  • Agitation
  • Decreased energy or fatigue
  • Feelings of guilt, worthlessness, or helplessness
  • Loss of interest or pleasure in activities once enjoyed, including sex
  • Prolonged sad, hopeless, or empty mood
  • Restlessness or diminished movements
  • Sleeping too much or too little
  • Thoughts of death or suicide with or without suicide attempts
  • Trouble concentrating, remembering, and/or making decisions
  • Unintended weight loss or gain

Severe episodes of mania or depression may sometimes be associated with psychotic symptoms such as:

  • Delusions
  • Disorders of thought
  • Hallucinations
Diagnosis

Your doctor will ask about your symptoms and medical history. A physical exam may be done. In some cases, lab tests are ordered. They will help to rule out other causes of mood and behavior symptoms. You may be referred to a mental health specialist. Diagnosis of bipolar disorder is based on:

  • Absence of other causes, such as some medicines and certain conditions
  • Family history of bipolar disorder
  • Presence of certain symptoms over time

Mania is diagnosed if:

  • Mood is elevated and there are three or more manic symptoms (listed above)
    • If the mood is irritable, not elevated, four symptoms must be present for a diagnosis of mania
  • Symptoms last during most of the day, nearly every day, for one week or longer

A depressive episode is diagnosed if:

  • Symptoms last for most of the day, nearly every day, for a period of two weeks or longer
  • There are five or more of the depressive symptoms (listed above)

Some medicines, illicit drugs, and conditions may show similar features, such as:

The diagnosis is made only when none of these causes are present.

Treatment

Talk with your doctor about the best plan for you.

Medications

The primary treatment is with medicines called mood stabilizers. There are many different types and combinations of medicines, which must be tailored by your doctor to target your symptoms. Examples of common medicines used to treat bipolar disorder include:

  • Antidepressants (serotonin reuptake inhibitors or bupropion [Wellbutrin])—used to treat depression, usually prescribed in combination with a mood stabilizer, like lithium
  • Antipsychotic medicines—used for acute manic or mixed episodes and maintenance treatment
    • Atypical antipsychotic medicines (eg, risperidone , olanzapine , aripiprazole , ziprasidone , and quetiapine )—more effective with less risk of tardive dyskinesia
    • Classic antipsychotic medicines (eg, haloperidol [Haldol])— not often used because of risks of tardive dyskinesia (uncontrollable movements)
  • Antiseizure medicines—also used as mood stabilizers instead or in combination with lithium
    • Carbamazepine (Tegretol)——often used if lithium or depakote cannot be taken or tolerated
    • Depakote (Valproate)—one of the most effective antiseizure medicines for treating and preventing mania
    • Lamotrigine (Lamictal)—usually used in treating people who spend most of the time in the depressed phase of the illness, also helps to prevent manic episodes
    • Topiramate (Topamax)
  • Benzodiazepines—a potentially addicting class of medicines that can be used to treat agitation or insomnia , usually on a short term basis
    • Clonazepam (Klonopin)
    • Lorazepam (Ativan)
  • Lithium —the oldest and most effective mood stabilizer, often used as initial treatment (helps prevent manic and depressive episodes from returning)
  • Zolpidem (Ambien)—used to treat insomnia

The plan is based on the pattern of the illness. Treatment may need to be continued indefinitely. It should prevent significant mood swings.

Psychotherapy

Psychotherapy is often an integral component of a comprehensive treatment plan. Therapy may include:

  • Cognitive-behavioral therapy
  • Counseling
  • Family therapy
  • Interpersonal and social rhythm therapy, a form of therapy designed to treat bipolar disorder
Electroconvulsive Therapy

Electroconvulsive therapy may be effective when medicines fail. It can be used for both mania and depression.

Prevention

There are no guidelines for preventing bipolar disorder. Taking your daily medicine and following your treatment plan can help prevent future mood episodes from recurring.

Last reviewed: September 2011 by Ryan Estevez, MD, PhD, MPH.

RESOURCES:
CANADIAN RESOURCES:
References:
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